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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $110 | 35 days | |
5 mg | $295 | 35 days | |
10 mg | $483 | 35 days | |
25 mg | $1,060 | 35 days |
Description | SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively). |
In vitro | SB-277011 dihydrochloride is a selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor, and restores ≥100-fold selectivity against the D2, 5-HT1B, and 5-HT1D receptors(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively). |
In vivo | the effects of quinelorane in the nucleus accumbens completely reversed by SB-277011 dihydrochloride (SB 277011; 3 mg/kg, p.o.), but does not reverse the effects of quinelorane in the striatum at 93 mg/kg in rats. |
Alias | SB-277011A dihydrochloride |
Molecular Weight | 511.49 |
Formula | C28H32Cl2N4O |
Cas No. | 1226917-67-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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